Reactome | HS3ST1 sulfates GlcN at C3 in heparan sulfate

Schema > Reaction > Entries

HS3ST1 sulfates GlcN at C3 in heparan sulfate Show undefined attributes

catalystActivity	[CatalystActivity:10500318] [heparan sulfate]-glucosamine 3-sulfotransferase activity of HS3ST1 [Golgi lumen]
category	transition
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10500320
displayName	HS3ST1 sulfates GlcN at C3 in heparan sulfate
eventOf	[Pathway:R-SSC-2022928] HS-GAG biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-2024108] Some HSPGs are secreted to the plasma membrane - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
inferredFrom	[Reaction:R-HSA-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate - Homo sapiens
input	[DefinedSet:R-SSC-2076297] HS(3)-PGs [Golgi lumen] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	HS3ST1 sulfates GlcN at C3 in heparan sulfate
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-SSC-2076491] HS(4)-PGs [Golgi lumen] [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-SSC-2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate - Sus scrofa [Reaction:R-SSC-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2076383
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2022928] HS-GAG biosynthesis
(precedingEvent)	[BlackBoxEvent:R-SSC-2024108] Some HSPGs are secreted to the plasma membrane
(inferredTo)	[Reaction:R-HSA-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate

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