Reactome | HS-GAG biosynthesis

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HS-GAG biosynthesis Show undefined attributes

created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10425422
displayName	HS-GAG biosynthesis
eventOf	[Pathway:R-SSC-1638091] Heparan sulfate/heparin (HS-GAG) metabolism - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-744231] SLC35D2 exchanges UDP-GlcNAc for UMP - Sus scrofa [Reaction:R-SSC-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Sus scrofa [Reaction:R-SSC-2022856] EXT1:EXT2 transfers GlcNAc to heparan - Sus scrofa [Reaction:R-SSC-2022851] EXT1:EXT2 transfer GlcNAc to the heparan chain - Sus scrofa [Reaction:R-SSC-2076392] EXT1:EXT2 transfers GlcA to heparan - Sus scrofa [Reaction:R-SSC-2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan - Sus scrofa [Reaction:R-SSC-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) - Sus scrofa [Reaction:R-SSC-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Sus scrofa [Reaction:R-SSC-2076611] HS3STs sulfate GlcN at C3 in heparan sulfate - Sus scrofa [Reaction:R-SSC-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate - Sus scrofa [Reaction:R-SSC-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Sus scrofa [BlackBoxEvent:R-SSC-2024108] Some HSPGs are secreted to the plasma membrane - Sus scrofa
inferredFrom	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
name	HS-GAG biosynthesis
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2022928
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1638091] Heparan sulfate/heparin (HS-GAG) metabolism
(inferredTo)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis

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