Reactome | Reduction of desmosterol to cholesterol

Schema > Reaction > Entries

Reduction of desmosterol to cholesterol Show undefined attributes

catalystActivity	[CatalystActivity:10464573] Delta24-sterol reductase activity of DHCR24 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10464575
displayName	Reduction of desmosterol to cholesterol
eventOf	[Pathway:R-SSC-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5250531] ARV1 transports CHOL from ER membrane to plasma membrane - Sus scrofa
inferredFrom	[Reaction:R-HSA-196417] Reduction of desmosterol to cholesterol - Homo sapiens
input	[SimpleEntity:R-ALL-196420] DESMOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Reduction of desmosterol to cholesterol desmosterol + NADPH + H(+) => cholesterol + NADP(+)
output	[SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-SSC-196402] Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-196417
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-SSC-5250531] ARV1 transports CHOL from ER membrane to plasma membrane
(inferredTo)	[Reaction:R-HSA-196417] Reduction of desmosterol to cholesterol

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