Reactome | CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol

Schema > Reaction > Entries

CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol Show undefined attributes

catalystActivity	[CatalystActivity:10463659] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10464169
displayName	CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol
eventOf	[Pathway:R-SSC-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-193719] 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al - Sus scrofa
inferredFrom	[Reaction:R-HSA-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - Homo sapiens
input	[SimpleEntity:R-ALL-193720] 5?-CHOL3?,7?,24(s)-triol [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol 5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADP+ + H2O
output	[SimpleEntity:R-ALL-193708] 5bCHOL3a,7a,24(s),27-tetrol [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-193792
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(precedingEvent)	[Reaction:R-SSC-193719] 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al
(inferredTo)	[Reaction:R-HSA-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol

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