Reactome | EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-8951489] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] - Sus scrofa [Complex:R-SSC-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] - Sus scrofa [Complex:R-SSC-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Sus scrofa [Reaction:R-SSC-183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10462389
displayName	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane]
hasComponent	[Complex:R-SSC-8875480] CIN85:endophilin [cytosol] 2 × [DefinedSet:R-SSC-9624194] EGF-like ligands [extracellular region] 2 × [EntityWithAccessionedSequence:R-SSC-74686] GRB2 [cytosol] 2 × [EntityWithAccessionedSequence:R-SSC-182923] phospho-CBL [plasma membrane] 2 × [EntityWithAccessionedSequence:R-SSC-179803] phospho-p-6Y-EGFR [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] - Homo sapiens
maxDepth	5
name	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin
producedByEvent	[Reaction:R-SSC-182994] Assembly of EGFR complex in clathrin-coated vesicles - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-182946
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-SSC-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-SSC-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-SSC-8951489] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane]
(input)	[Reaction:R-SSC-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-SSC-183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
(output)	[Reaction:R-SSC-182994] Assembly of EGFR complex in clathrin-coated vesicles
(inferredTo)	[Complex:R-HSA-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane]

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