Reactome | Binding of ATR-ATRIP to the RPA-ssDNA complex

Schema > Reaction > Entries

Binding of ATR-ATRIP to the RPA-ssDNA complex Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10461693
displayName	Binding of ATR-ATRIP to the RPA-ssDNA complex
eventOf	[Pathway:R-SSC-176187] Activation of ATR in response to replication stress - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-176298] Activation of claspin - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
inferredFrom	[Reaction:R-HSA-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex - Homo sapiens
input	[Complex:R-SSC-176269] ATR:ATRIP [nucleoplasm] [Complex:R-SSC-176293] RPA complexed to ssDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of ATR-ATRIP to the RPA-ssDNA complex
output	[Complex:R-SSC-176281] ATR:ATRIP:RPA:ssDNA signaling complex [nucleoplasm]
precedingEvent	[Reaction:R-SSC-176175] Stalling of DNA replication fork and RPA binding - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-176250
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-176187] Activation of ATR in response to replication stress
(precedingEvent)	[Reaction:R-SSC-176298] Activation of claspin
(inferredTo)	[Reaction:R-HSA-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex

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