Reactome | CDC25A dephosphorylates CCNA:CDK1

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CDC25A dephosphorylates CCNA:CDK1 Show undefined attributes

catalystActivity	[CatalystActivity:10447942] phosphoprotein phosphatase activity of CDC25A [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10459846
displayName	CDC25A dephosphorylates CCNA:CDK1
eventOf	[Pathway:R-SSC-69273] Cyclin A/B1/B2 associated events during G2/M transition - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-4088024] CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 - Sus scrofa [Reaction:R-SSC-9929514] CDK1 phosphorylates CCNA - Sus scrofa
inferredFrom	[Reaction:R-HSA-170158] CDC25A dephosphorylates CCNA:CDK1 - Homo sapiens
input	[CandidateSet:R-SSC-170147] CCNA:p-T14,Y15,T161-CDK1 [nucleoplasm] 2 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDC25A dephosphorylates CCNA:CDK1 Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
output	[CandidateSet:R-SSC-170146] CCNA:p-T161-CDK1 [nucleoplasm] 2 × [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[Reaction:R-SSC-170156] WEE1 phosphorylates CCNA:CDK1 - Sus scrofa [Reaction:R-SSC-170159] Translocation of Cdc25 to the nucleus - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-170158
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-69273] Cyclin A/B1/B2 associated events during G2/M transition
(precedingEvent)	[Reaction:R-SSC-4088024] CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 [Reaction:R-SSC-9929514] CDK1 phosphorylates CCNA
(inferredTo)	[Reaction:R-HSA-170158] CDC25A dephosphorylates CCNA:CDK1

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