Reactome | PC is hydrolyzed to PA and choline by PLD1/2

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PC is hydrolyzed to PA and choline by PLD1/2 Show undefined attributes

catalystActivity	[CatalystActivity:10492842] D-type glycerophospholipase activity of PLD1/2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10492844
displayName	PC is hydrolyzed to PA and choline by PLD1/2
eventOf	[Pathway:R-SSC-1483166] Synthesis of PA - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1483004] Cho is phosphorylated to PCho by CHK dimer - Sus scrofa [Reaction:R-SSC-1483203] PA is dephosphorylated to DAG by LPIN - Sus scrofa [Reaction:R-SSC-264622] Cho is acetylated to AcCho by CHAT - Sus scrofa [Reaction:R-SSC-1483121] PA is converted to CDP-DAG by CDS1 - Sus scrofa [Reaction:R-SSC-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Sus scrofa [Reaction:R-SSC-1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A - Sus scrofa
inferredFrom	[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PC is hydrolyzed to PA and choline by PLD1/2
output	[SimpleEntity:R-ALL-264618] Cho [cytosol] [SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SSC-1483219] PC is exchanged with PI by PITPNB - Sus scrofa [Reaction:R-SSC-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Sus scrofa [Reaction:R-SSC-1482547] 1-acyl LPC is acylated to PC by LPCAT - Sus scrofa [Reaction:R-SSC-1482533] 2-acyl LPC is acylated to PC by LPCAT - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1483182
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1483166] Synthesis of PA
(precedingEvent)	[Reaction:R-SSC-264622] Cho is acetylated to AcCho by CHAT [Reaction:R-SSC-1483121] PA is converted to CDP-DAG by CDS1 [Reaction:R-SSC-1483004] Cho is phosphorylated to PCho by CHK dimer [Reaction:R-SSC-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] [Reaction:R-SSC-1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A [Reaction:R-SSC-1483203] PA is dephosphorylated to DAG by LPIN
(inferredTo)	[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2

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