Reactome | AQP1 tetramer transports CO2 from extracellular region to cytosol

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AQP1 tetramer transports CO2 from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10489898] carbon dioxide transmembrane transporter activity of AQP1 tetramer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10489900
displayName	AQP1 tetramer transports CO2 from extracellular region to cytosol
eventOf	[Pathway:R-SSC-1237044] Erythrocytes take up carbon dioxide and release oxygen - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1475435] CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- - Sus scrofa [Reaction:R-SSC-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Sus scrofa
inferredFrom	[Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-1237009] CO2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	AQP1 tetramer transports CO2 from extracellular region to cytosol AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol]
precedingEvent	[Reaction:R-SSC-70967] IDH3 complex decarboxylates isocitrate - Sus scrofa [Reaction:R-SSC-450984] IDH2 dimer decarboxylates isocitrate - Sus scrofa [Reaction:R-SSC-71401] OGDH dimer decarboxylates 2-OG - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1237042
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1237044] Erythrocytes take up carbon dioxide and release oxygen
(precedingEvent)	[Reaction:R-SSC-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen [Reaction:R-SSC-1475435] CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-
(inferredTo)	[Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol

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