Reactome | RFC binding displaces Pol Alpha

Schema > Reaction > Entries

RFC binding displaces Pol Alpha Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11051867
displayName	RFC binding displaces Pol Alpha
eventOf	[Pathway:R-SPO-69091] Polymerase switching - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-69063] Loading of PCNA - Sliding Clamp Formation - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-69053] RFC binding displaces Pol Alpha - Homo sapiens
input	[Complex:R-SPO-68436] RFC Heteropentamer [nucleoplasm] [Complex:R-SPO-68425] RNA primer-DNA primer:origin duplex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RFC binding displaces Pol Alpha
output	[Complex:R-SPO-68437] RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm]
precedingEvent	[Reaction:R-SPO-68950] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-69053
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-69091] Polymerase switching
(precedingEvent)	[Reaction:R-SPO-69063] Loading of PCNA - Sliding Clamp Formation
(inferredTo)	[Reaction:R-HSA-69053] RFC binding displaces Pol Alpha