Reactome | PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

Schema > Reaction > Entries

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus Show undefined attributes

catalystActivity	[CatalystActivity:11072337] 1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11072339
displayName	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus
eventOf	[Pathway:R-SPO-8847453] Synthesis of PIPs in the nucleus - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-6810408] PI5P [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-6810412] PI(4,5)P2 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-6811522
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-8847453] Synthesis of PIPs in the nucleus [Pathway:R-SPO-6811555] PI5P Regulates TP53 Acetylation
(inferredTo)	[Reaction:R-HSA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

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