Reactome | Addition of the first mannose to the N-glycan precursor by ALG1

Schema > Reaction > Entries

Addition of the first mannose to the N-glycan precursor by ALG1 Show undefined attributes

catalystActivity	[CatalystActivity:11060870] chitobiosyldiphosphodolichol beta-mannosyltransferase activity of ALG1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11060872
displayName	Addition of the first mannose to the N-glycan precursor by ALG1
eventOf	[Pathway:R-SPO-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-446208] Addition of a second mannose to the N-glycan precursor by ALG2 - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-446218] Addition of the first mannose to the N-glycan precursor by ALG1 - Homo sapiens
input	[SimpleEntity:R-ALL-162860] GDP-Man [cytosol] [SimpleEntity:R-ALL-449293] N,N'-DCDOLDP [cytoplasmic side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Addition of the first mannose to the N-glycan precursor by ALG1
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [SimpleEntity:R-ALL-449283] MDCDD [cytoplasmic side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SPO-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-446218
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(precedingEvent)	[Reaction:R-SPO-446208] Addition of a second mannose to the N-glycan precursor by ALG2
(inferredTo)	[Reaction:R-HSA-446218] Addition of the first mannose to the N-glycan precursor by ALG1

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