Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

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Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Show undefined attributes

created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11078733
displayName	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
eventOf	[Pathway:R-SPO-446203] Asparagine N-linked glycosylation - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:18691] dolichol-linked oligosaccharide biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-SPO-446219] Synthesis of substrates in N-glycan biosythesis - Schizosaccharomyces pombe [Reaction:R-SPO-446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate - Schizosaccharomyces pombe [Reaction:R-SPO-446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - Schizosaccharomyces pombe [Reaction:R-SPO-446218] Addition of the first mannose to the N-glycan precursor by ALG1 - Schizosaccharomyces pombe [Reaction:R-SPO-446208] Addition of a second mannose to the N-glycan precursor by ALG2 - Schizosaccharomyces pombe [Reaction:R-SPO-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Schizosaccharomyces pombe [Reaction:R-SPO-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Schizosaccharomyces pombe [Reaction:R-SPO-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Schizosaccharomyces pombe [Reaction:R-SPO-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 - Schizosaccharomyces pombe [Reaction:R-SPO-446202] Addition of the first glucose to the N-glycan precursor by ALG6 - Schizosaccharomyces pombe [Reaction:R-SPO-446189] Addition of a second glucose to the N-glycan precursor by ALG8 - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-446193
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-446203] Asparagine N-linked glycosylation
(inferredTo)	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

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