Reactome | ZIP7 mediates zinc efflux from the endoplasmic reticulum

Schema > Reaction > Entries

ZIP7 mediates zinc efflux from the endoplasmic reticulum Show undefined attributes

catalystActivity	[CatalystActivity:11060673] zinc ion transmembrane transporter activity of SLC39A7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11060675
displayName	ZIP7 mediates zinc efflux from the endoplasmic reticulum
eventOf	[Pathway:R-SPO-442380] Zinc influx into cells by the SLC39 gene family - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Schizosaccharomyces pombe [Reaction:R-SPO-9820566] ZnT5 transports zinc into the golgi apparatus - Schizosaccharomyces pombe [Reaction:R-SPO-435366] ZnT1 mediates the efflux of zinc from the cell - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum - Homo sapiens
input	[SimpleEntity:R-ALL-442320] Zn2+ [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	ZIP7 mediates zinc efflux from the endoplasmic reticulum
output	[SimpleEntity:R-ALL-29426] Zn2+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-442393
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-SPO-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells [Reaction:R-SPO-9820566] ZnT5 transports zinc into the golgi apparatus [Reaction:R-SPO-435366] ZnT1 mediates the efflux of zinc from the cell
(hasEvent)	[Pathway:R-SPO-442380] Zinc influx into cells by the SLC39 gene family
(inferredTo)	[Reaction:R-HSA-442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum