Reactome | KEAP1-NFE2L2 pathway

Schema > Pathway > Entries

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107916
displayName	KEAP1-NFE2L2 pathway
eventOf	[Pathway:R-SCE-9711123] Cellular response to chemical stress - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SCE-9758088] UBXN7 binds VCP hexamer:UBF1:NPLOC4 - Saccharomyces cerevisiae [Pathway:R-SCE-9759194] Nuclear events mediated by NFE2L2 - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	KEAP1-NFE2L2 pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9755511
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEncapsulatedEvent)	[Pathway:R-SCE-8951664] Neddylation [Pathway:R-SCE-9707564] Cytoprotection by HMOX1
(hasEvent)	[Pathway:R-SCE-9711123] Cellular response to chemical stress
(inferredTo)	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway

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