Reactome | GUK1 phosphorylates 6TGMP to 6TGDP

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GUK1 phosphorylates 6TGMP to 6TGDP Show undefined attributes

catalystActivity	[CatalystActivity:11083010] GMP kinase activity of GUK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11105177
displayName	GUK1 phosphorylates 6TGMP to 6TGDP
eventOf	[Pathway:R-SCE-9748787] Azathioprine ADME - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-9748999] NME1:2 hexamer phosphorylates 6TGDP to 6TGTP - Saccharomyces cerevisiae
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
inferredFrom	[Reaction:R-HSA-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Homo sapiens
input	[SimpleEntity:R-ALL-9748970] 6TGMP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GUK1 phosphorylates 6TGMP to 6TGDP 6TGMP--MPK-->6TGDP
output	[SimpleEntity:R-ALL-9748960] 6TGDP [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-SCE-9748957] GMPS dimer transforms 6TXMP to 6TGMP - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9748949
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-9748787] Azathioprine ADME
(precedingEvent)	[Reaction:R-SCE-9748999] NME1:2 hexamer phosphorylates 6TGDP to 6TGTP
(inferredTo)	[Reaction:R-HSA-9748949] GUK1 phosphorylates 6TGMP to 6TGDP

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