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Entries
GUK1 phosphorylates 6TGMP to 6TGDP
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authored
[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
catalystActivity
[CatalystActivity:74189] GMP kinase activity of GUK1 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
dbId
9748949
displayName
GUK1 phosphorylates 6TGMP to 6TGDP
edited
[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
eventOf
[Pathway:R-HSA-9748787] Azathioprine ADME - Homo sapiens
followingEvent
[Reaction:R-HSA-9748999] NME1:2 hexamer phosphorylates 6TGDP to 6TGTP - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:8764] xenobiotic metabolic process
input
[SimpleEntity:R-ALL-9748970] 6TGMP [cytosol]
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:110117] Guanylate kinases from human erythrocytes, hog brain, and rat liver
[LiteratureReference:9749708] Reassessment of the interactions of guanylate kinase and 6-thioguanosine 5'-phosphate
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
GUK1 phosphorylates 6TGMP to 6TGDP
6TGMP--MPK-->6TGDP
orthologousEvent
[Reaction:R-PFA-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Plasmodium falciparum
[Reaction:R-SCE-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Saccharomyces cerevisiae
[Reaction:R-SPO-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Schizosaccharomyces pombe
[Reaction:R-DDI-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Dictyostelium discoideum
[Reaction:R-CEL-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Caenorhabditis elegans
[Reaction:R-DME-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Drosophila melanogaster
[Reaction:R-GGA-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Gallus gallus
[Reaction:R-XTR-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Xenopus tropicalis
[Reaction:R-DRE-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Danio rerio
[Reaction:R-SSC-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Sus scrofa
[Reaction:R-BTA-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Bos taurus
[Reaction:R-CFA-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Canis familiaris
[Reaction:R-RNO-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Rattus norvegicus
[Reaction:R-MMU-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Mus musculus
output
[SimpleEntity:R-ALL-9748960] 6TGDP [cytosol]
[SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent
[Reaction:R-HSA-9748957] GMPS dimer transforms 6TXMP to 6TGMP - Homo sapiens
releaseDate
2021-12-08
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9756856] Huddart, Rachel, 2021-10-19
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9748949
summation
[Summation:9749709] 6-thioguanine nucleotides (6-TGNs) consist of 6-thio(deoxy)g...
Referrals
(precedingEvent)
[Reaction:R-HSA-9748999] NME1:2 hexamer phosphorylates 6TGDP to 6TGTP
(hasEvent)
[Pathway:R-HSA-9748787] Azathioprine ADME
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