Reactome | OGFOD1:Fe2+ hydroxylates a proline residue of RPS23

Schema > Reaction > Entries

OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 Show undefined attributes

catalystActivity	[CatalystActivity:11104518] peptidyl-proline 3-dioxygenase activity of OGFOD1:Fe2+ [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11104520
displayName	OGFOD1:Fe2+ hydroxylates a proline residue of RPS23
eventOf	[Pathway:R-SCE-9629569] Protein hydroxylation - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:3962] peptidyl-proline hydroxylation
inferredFrom	[Reaction:R-HSA-9630769] OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 - Homo sapiens
input	[SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [DefinedSet:R-SCE-6791209-3] Homologues of RPS23 [nucleoplasm] [SimpleEntity:R-ALL-113685] O2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 2-oxoglutarate + (ribosomal protein uS12)-L-proline + O2 => (ribosomal protein uS12)-(3S)-3-hydroxy-L-proline + CO2 + succinate
output	[SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [DefinedSet:R-SCE-9630773-3] Homologues of 3OHP62-RPS23 [nucleoplasm] [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9630769
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-9629569] Protein hydroxylation
(inferredTo)	[Reaction:R-HSA-9630769] OGFOD1:Fe2+ hydroxylates a proline residue of RPS23

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