Reactome | Recycling of eIF2:GDP

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11106806
displayName	Recycling of eIF2:GDP
eventOf	[Pathway:R-SCE-72737] Cap-dependent Translation Initiation - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SCE-72670] Formation of eIF2:GDP:eIF2B intermediate - Saccharomyces cerevisiae [Reaction:R-SCE-72722] eIF2 activation - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-72731] Recycling of eIF2:GDP - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Recycling of eIF2:GDP
precedingEvent	[Pathway:R-SCE-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-72731
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SCE-72737] Cap-dependent Translation Initiation
(inferredTo)	[Pathway:R-HSA-72731] Recycling of eIF2:GDP

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