Reactome | PDPK1 phosphorylates PKN1,2,3

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PDPK1 phosphorylates PKN1,2,3 Show undefined attributes

catalystActivity	[CatalystActivity:11095868] protein serine/threonine kinase activity of RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11095870
displayName	PDPK1 phosphorylates PKN1,2,3
eventOf	[Pathway:R-SCE-5625740] RHO GTPases activate PKNs - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-5671737] p-T774-PKN1 binds CDC25C - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-5623667] PDPK1 phosphorylates PKN1,2,3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SCE-5623637] RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PDPK1 phosphorylates PKN1,2,3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-SCE-5623659] p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] [Complex:R-SCE-109697] PDPK1:PIP3 [plasma membrane] [Complex:R-SCE-5624294] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-SCE-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-5623667
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-5625740] RHO GTPases activate PKNs
(precedingEvent)	[Reaction:R-SCE-5671737] p-T774-PKN1 binds CDC25C
(inferredTo)	[Reaction:R-HSA-5623667] PDPK1 phosphorylates PKN1,2,3