Reactome | Senescence-Associated Secretory Phenotype (SASP)

Schema > Pathway > Entries

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107280
displayName	Senescence-Associated Secretory Phenotype (SASP)
eventOf	[Pathway:R-SCE-2559583] Cellular Senescence - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SCE-198746] ERK1/2/5 activate RSK1/2/3 - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Senescence-Associated Secretory Phenotype (SASP)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-2559582
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SCE-2559583] Cellular Senescence
(hasEncapsulatedEvent)	[Pathway:R-SCE-2559580] Oxidative Stress Induced Senescence [Pathway:R-SCE-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-SCE-453279] Mitotic G1 phase and G1/S transition
(inferredTo)	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP)

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