Reactome | Oxidative Stress Induced Senescence

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Oxidative Stress Induced Senescence Show undefined attributes

created	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
crossReference	[DatabaseIdentifier:12325366] BioModels Database:BIOMD0000000116
dbId	10930115
displayName	Oxidative Stress Induced Senescence
eventOf	[Pathway:R-SCE-2559583] Cellular Senescence - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SCE-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Saccharomyces cerevisiae [Reaction:R-SCE-450348] Activated human JNKs migrate to nucleoplasm - Saccharomyces cerevisiae [Reaction:R-SCE-168136] Activated JNKs phosphorylate c-JUN - Saccharomyces cerevisiae [Reaction:R-SCE-8979071] KDM6B binds iron - Saccharomyces cerevisiae [Reaction:R-SCE-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
isInDisease	false
isInferred	true
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Oxidative Stress Induced Senescence
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-2559580
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-2559583] Cellular Senescence
(hasEncapsulatedEvent)	[Pathway:R-SCE-6804756] Regulation of TP53 Activity through Phosphorylation [Pathway:R-SCE-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-SCE-9833482] PKR-mediated signaling [Pathway:R-SCE-453279] Mitotic G1 phase and G1/S transition [Pathway:R-SCE-2559582] Senescence-Associated Secretory Phenotype (SASP)
(inferredTo)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence

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