Reactome | PC is hydrolyzed to PA and choline by PLD1/2

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PC is hydrolyzed to PA and choline by PLD1/2 Show undefined attributes

catalystActivity	[CatalystActivity:11091849] D-type glycerophospholipase activity of PLD1/2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11091851
displayName	PC is hydrolyzed to PA and choline by PLD1/2
eventOf	[Pathway:R-SCE-1483166] Synthesis of PA - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-264622] Cho is acetylated to AcCho by CHAT - Saccharomyces cerevisiae [Reaction:R-SCE-1483203] PA is dephosphorylated to DAG by LPIN - Saccharomyces cerevisiae [Reaction:R-SCE-1483004] Cho is phosphorylated to PCho by CHK dimer - Saccharomyces cerevisiae [Reaction:R-SCE-1483121] PA is converted to CDP-DAG by CDS1 - Saccharomyces cerevisiae [Reaction:R-SCE-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PC is hydrolyzed to PA and choline by PLD1/2
output	[SimpleEntity:R-ALL-264618] Cho [cytosol] [SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SCE-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Saccharomyces cerevisiae [Reaction:R-SCE-1482547] 1-acyl LPC is acylated to PC by LPCAT - Saccharomyces cerevisiae [Reaction:R-SCE-1482533] 2-acyl LPC is acylated to PC by LPCAT - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-1483182
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-1483166] Synthesis of PA
(precedingEvent)	[Reaction:R-SCE-264622] Cho is acetylated to AcCho by CHAT [Reaction:R-SCE-1483121] PA is converted to CDP-DAG by CDS1 [Reaction:R-SCE-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] [Reaction:R-SCE-1483203] PA is dephosphorylated to DAG by LPIN [Reaction:R-SCE-1483004] Cho is phosphorylated to PCho by CHK dimer
(inferredTo)	[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2