Reactome | Precursor Cargo of TIM23 SORT [mitochondrial inner membrane]

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Precursor Cargo of TIM23 SORT [mitochondrial inner membrane] Show undefined attributes

compartment	[Compartment:70616] mitochondrial inner membrane
componentOf	[Complex:R-SCE-1268007] TIM23 SORT:Precursor Cargo [mitochondrial inner membrane] - Saccharomyces cerevisiae
created	[InstanceEdit:1252211] May, B, 2011-04-27
dbId	1252213
displayName	Precursor Cargo of TIM23 SORT [mitochondrial inner membrane]
hasMember	[EntityWithAccessionedSequence:R-SCE-1252057] ATP2 precursor [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252164] ATP9 precursor [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252115] COQ2 precursor [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1267998] COX4 precursor [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1267990] COX5A precursor [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1267979] CYB2 precursor [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1267996] DLD1 precursor [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252046] TIM54 [mitochondrial inner membrane] - Saccharomyces cerevisiae
inDisease	false
inferredTo	[CandidateSet:R-HSA-1299465] Precursor Cargo of TIMM23 SORT [mitochondrial inner membrane] - Homo sapiens
literatureReference	[LiteratureReference:1252293] A cooperative action of the ATP-dependent import motor complex and the inner membrane potential drives mitochondrial preprotein import [LiteratureReference:1252351] Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria [LiteratureReference:1252319] Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway [LiteratureReference:1252356] Different import pathways through the mitochondrial intermembrane space for inner membrane proteins [LiteratureReference:1252342] Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase [LiteratureReference:1252368] Modular structure of the TIM23 preprotein translocase of mitochondria [LiteratureReference:1252348] Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria [LiteratureReference:1252357] The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44 [LiteratureReference:1252367] Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex TIM23 [LiteratureReference:1252350] Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import [LiteratureReference:1254306] Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain [LiteratureReference:1254317] Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor [LiteratureReference:1254313] Pam16 has an essential role in the mitochondrial protein import motor [LiteratureReference:1254323] A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria [LiteratureReference:1254309] Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane [LiteratureReference:1254321] The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70 [LiteratureReference:1254324] Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins
maxDepth	2
modified	[InstanceEdit:1467434] May, B, 2011-07-31
name	Precursor Cargo of TIM23 SORT Precursors Imported to the Inner Membrane by TIM23 SORT Complex
schemaClass	DefinedSet
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-1252213

Referrals

(hasComponent)

[Complex:R-SCE-1268007] TIM23 SORT:Precursor Cargo [mitochondrial inner membrane]

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