Reactome | Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase

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Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase Show undefined attributes

catalystActivity	[CatalystActivity:11084191] A2-type glycerophospholipase activity of p-S505,S727-PLA2G4A [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11084193
displayName	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
eventOf	[Pathway:R-SCE-111995] phospho-PLA2 pathway - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - Homo sapiens
input	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [DefinedSet:R-SCE-111859-5] Homologues of p-S505,S727-PLA2G4A [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
output	[Complex:R-SCE-111860] Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SCE-428961] Phosphorylation of cPLA2 by MAPK p38 alpha - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-111881
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-111995] phospho-PLA2 pathway
(precedingEvent)	[Reaction:R-SCE-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine
(inferredTo)	[Reaction:R-HSA-111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase

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