Reactome | Lanosterol biosynthesis

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Lanosterol biosynthesis Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223137
displayName	Lanosterol biosynthesis
eventOf	[Pathway:R-RNO-191273] Cholesterol biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20521] cholesterol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Rattus norvegicus [Reaction:R-RNO-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Rattus norvegicus [Reaction:R-RNO-191352] HMGCR dimer reduces bHMG-CoA to MVA - Rattus norvegicus [Reaction:R-RNO-9705584] HMGCR dimer binds statins - Rattus norvegicus [Reaction:R-RNO-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate - Rattus norvegicus [Reaction:R-RNO-191422] Mevalonate-5-phosphate is further phosphorylated - Rattus norvegicus [Reaction:R-RNO-191414] MVD decarboxylates MVA5PP to IPPP - Rattus norvegicus [Reaction:R-RNO-191382] Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate - Rattus norvegicus [Reaction:R-RNO-191322] FDPS dimer transfers IPPP to DMAPP - Rattus norvegicus [Reaction:R-RNO-9717834] GGPS1 hexamer transfers IPPP to DMAPP - Rattus norvegicus [Reaction:R-RNO-191303] FDPS dimer transfers IPPP to GPP - Rattus norvegicus [Reaction:R-RNO-9717830] GGPS1 hexamer transfers IPPP to GPP - Rattus norvegicus [Reaction:R-RNO-9717841] holo-FDPS dimer binds NBPs - Rattus norvegicus [Reaction:R-RNO-191405] Two FAPP molecules dimerize to form presqualene diphosphate - Rattus norvegicus [Reaction:R-RNO-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate - Rattus norvegicus [Reaction:R-RNO-191402] Reduction of presqualene diphosphate to form squalene - Rattus norvegicus [Reaction:R-RNO-191299] Squalene is oxidized to its epoxide - Rattus norvegicus [Reaction:R-RNO-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9969896] Lanosterol biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Lanosterol biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9969896
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-191273] Cholesterol biosynthesis
(inferredTo)	[Pathway:R-HSA-9969896] Lanosterol biosynthesis

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