Reactome | Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate

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Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10205822] hydrolase activity of PLPP6 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10205824
displayName	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
eventOf	[Pathway:R-RNO-9969896] Lanosterol biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-191265] PSQPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate presqualene diphosphate + H2O => presqualene phosphate + phosphate + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-8952135] PSMP [cytosol]
precedingEvent	[Reaction:R-RNO-191405] Two FAPP molecules dimerize to form presqualene diphosphate - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8952137
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9969896] Lanosterol biosynthesis
(inferredTo)	[Reaction:R-HSA-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate

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