Reactome | GBP-mediated host defense

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GBP-mediated host defense Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225541
displayName	GBP-mediated host defense
eventOf	[Pathway:R-RNO-1169410] Antimicrobial mechanism of IFN-stimulated genes - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9715851] defense response to symbiont
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-9948016] FNTA:FNTB transfers farnesyl to GBP1 - Rattus norvegicus [Reaction:R-RNO-9947999] FNTA:PGGT1B geranylgeranylates GBP2 - Rattus norvegicus [Reaction:R-RNO-9954195] FNTA:PGGT1B geranylgeranylates GBP5 - Rattus norvegicus [Reaction:R-RNO-9968553] GBP1 binds GTP - Rattus norvegicus [Reaction:R-RNO-9947932] GBP1:GTP binds LPS on the bacterial surface - Rattus norvegicus [Reaction:R-RNO-9947887] GBP1 hydrolyzes GDP - Rattus norvegicus [Reaction:R-RNO-9953173] GMP dissociates from the GBP1 oligomer - Rattus norvegicus [Polymerisation:R-RNO-9947876] GBP1:GBP2:GBP3:GBP4 forms higher-order structures - Rattus norvegicus [Reaction:R-RNO-9954252] GGC-GBP2, GGC-GBP5 bind furin - Rattus norvegicus [Reaction:R-RNO-9956706] GBP1 binds actin - Rattus norvegicus [Pathway:R-RNO-9968551] Regulation of GBP-mediated host defense - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9953170] GBP-mediated host defense - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	GBP-mediated host defense
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9953170
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1169410] Antimicrobial mechanism of IFN-stimulated genes
(inferredTo)	[Pathway:R-HSA-9953170] GBP-mediated host defense

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