Reactome | FNTA:PGGT1B geranylgeranylates GBP2

Schema > Reaction > Entries

FNTA:PGGT1B geranylgeranylates GBP2 Show undefined attributes

catalystActivity	[CatalystActivity:10221365] CAAX-protein geranylgeranyltransferase activity of FNTA:PGGT1B:Zn2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10221367
displayName	FNTA:PGGT1B geranylgeranylates GBP2
eventOf	[Pathway:R-RNO-9953170] GBP-mediated host defense - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9954252] GGC-GBP2, GGC-GBP5 bind furin - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9947999] FNTA:PGGT1B geranylgeranylates GBP2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-1015673] GBP2 [cytosol] [SimpleEntity:R-ALL-9947981] GGPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FNTA:PGGT1B geranylgeranylates GBP2 FNTA:PGGT1B transfers GGPP to GBP2 GBP2 prenylation
output	[EntityWithAccessionedSequence:R-RNO-9947851] GGC-C588-GBP2 [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9947999
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9953170] GBP-mediated host defense
(precedingEvent)	[Reaction:R-RNO-9954252] GGC-GBP2, GGC-GBP5 bind furin
(inferredTo)	[Reaction:R-HSA-9947999] FNTA:PGGT1B geranylgeranylates GBP2

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