Reactome | Co-inhibition by BTLA

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Co-inhibition by BTLA Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223627
displayName	Co-inhibition by BTLA
eventOf	[Pathway:R-RNO-388841] Regulation of T cell activation by CD28 family - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:173020] T cell costimulation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-389523] BTLA interacts with HVEM - Rattus norvegicus [Reaction:R-RNO-389919] Grb2 binds pBTLA - Rattus norvegicus [Reaction:R-RNO-389941] SHP-1 and SHP-2 bind pBTLA - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9927353] Co-inhibition by BTLA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Co-inhibition by BTLA BTLA inhibitory Signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9927353
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-388841] Regulation of T cell activation by CD28 family
(inferredTo)	[Pathway:R-HSA-9927353] Co-inhibition by BTLA

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