Reactome | Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177

Schema > Reaction > Entries

Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 Show undefined attributes

catalystActivity	[CatalystActivity:10218960] protein serine kinase activity of p-T308,S473-AKT1:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10218962
displayName	Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177
eventOf	[Pathway:R-RNO-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9860808] p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9860792] Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-203639] palmitoylated, myristoylated eNOS dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-203564] p-S1177-eNOS dimer [plasma membrane]
precedingEvent	[Reaction:R-RNO-9860759] p-T816-PKN2 phosphorylates AKT1 on serine-308 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9860792
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
(precedingEvent)	[Reaction:R-RNO-9860808] p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179
(inferredTo)	[Reaction:R-HSA-9860792] Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177

Cite Us!