Reactome | p-T816-PKN2 phosphorylates AKT1 on serine-308

Schema > Reaction > Entries

p-T816-PKN2 phosphorylates AKT1 on serine-308 Show undefined attributes

catalystActivity	[CatalystActivity:10218947] protein tyrosine kinase activity of p-T816-PKN2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10218949
displayName	p-T816-PKN2 phosphorylates AKT1 on serine-308
eventOf	[Pathway:R-RNO-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9860792] Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9860759] p-T816-PKN2 phosphorylates AKT1 on serine-308 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-377272] p-S473-AKT1:PIP3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-T816-PKN2 phosphorylates AKT1 on serine-308
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-202323] p-T308,S473-AKT1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-RNO-9860785] PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 - Rattus norvegicus [Reaction:R-RNO-9860800] mTORC2 phosphorylates AKT1 on serine-473 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9860759
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
(precedingEvent)	[Reaction:R-RNO-9860792] Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177
(inferredTo)	[Reaction:R-HSA-9860759] p-T816-PKN2 phosphorylates AKT1 on serine-308