Reactome | Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1

Schema > Reaction > Entries

Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10218783
displayName	Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1
eventOf	[Pathway:R-RNO-9841251] Mitochondrial unfolded protein response (UPRmt) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9857076] Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 - Homo sapiens
input	[Complex:R-RNO-9857081] HSF1:HSPA1A,B [cytosol] [EntityWithAccessionedSequence:R-RNO-9857072] SOH-C149,C150-DNAJA1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1
output	[EntityWithAccessionedSequence:R-RNO-3371452] Hsf1 [cytosol] [Complex:R-RNO-9857087] HSPA1A,B:ox-C149,C150-DNAJA1 [cytosol]
precedingEvent	[Reaction:R-RNO-9857090] Reactive oxygen species oxidize DNAJA1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9857076
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9841251] Mitochondrial unfolded protein response (UPRmt)
(precedingEvent)	[BlackBoxEvent:R-RNO-9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization
(inferredTo)	[Reaction:R-HSA-9857076] Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1

Cite Us!