Reactome | TGFB1,TGFB2 bind TGFBR3

Schema > Reaction > Entries

TGFB1,TGFB2 bind TGFBR3 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10217569
displayName	TGFB1,TGFB2 bind TGFBR3
eventOf	[Pathway:R-RNO-9839389] TGFBR3 regulates TGF-beta signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9839402] TGFBR3 binding to GIPC1 - Rattus norvegicus [Reaction:R-RNO-9839390] TGFBR3 complex binds to TGFBR2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9839377] TGFB1,TGFB2 bind TGFBR3 - Homo sapiens
input	[DefinedSet:R-RNO-9839339] TGFB1,TGFB2 [extracellular region] [EntityWithAccessionedSequence:R-RNO-9839336] Tgfbr3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TGFB1,TGFB2 bind TGFBR3
output	[Complex:R-RNO-9839342] TGFB1,TGFB2:TGFBR3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-RNO-9839388] TGFBR3 translocation to plasma membrane - Rattus norvegicus
regulatedBy	[NegativeRegulation:10118036] Negative regulation by 'TGFBR3(1-783):TGFB1,TGFB2 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9839377
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9839389] TGFBR3 regulates TGF-beta signaling
(precedingEvent)	[Reaction:R-RNO-9839402] TGFBR3 binding to GIPC1 [Reaction:R-RNO-9839390] TGFBR3 complex binds to TGFBR2
(inferredTo)	[Reaction:R-HSA-9839377] TGFB1,TGFB2 bind TGFBR3