Reactome | Interaction of beta-2-microglobulin (B2M) chain with class I HC

Schema > Reaction > Entries

Interaction of beta-2-microglobulin (B2M) chain with class I HC Show undefined attributes

category	transition
compartment	[Compartment:5263265] lumenal side of endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10149497
displayName	Interaction of beta-2-microglobulin (B2M) chain with class I HC
eventOf	[Pathway:R-RNO-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-983142] Formation of peptide loading complex (PLC) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-983146] Interaction of beta-2-microglobulin (B2M) chain with class I HC - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-983063] B2m [endoplasmic reticulum lumen] [Complex:R-RNO-983119] MHC class I HC:Calnexin/BiP:Erp57 [lumenal side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of beta-2-microglobulin (B2M) chain with class I HC
output	[CandidateSet:R-RNO-983129] Chaperones calnexin/BiP [lumenal side of endoplasmic reticulum membrane] [Complex:R-RNO-983136] MHC HC:B2M:Erp57 [lumenal side of endoplasmic reticulum membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-983146
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC
(precedingEvent)	[Reaction:R-RNO-983142] Formation of peptide loading complex (PLC)
(inferredTo)	[Reaction:R-HSA-983146] Interaction of beta-2-microglobulin (B2M) chain with class I HC

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