Reactome | Amplification and propagation of coagulation cascade

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Amplification and propagation of coagulation cascade Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222669
displayName	Amplification and propagation of coagulation cascade
eventOf	[Pathway:R-RNO-9769740] Coagulation pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-RNO-9853809] ANO6 exposes PS, PE on the platelet membrane - Rattus norvegicus [Reaction:R-RNO-158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - Rattus norvegicus [Reaction:R-RNO-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Rattus norvegicus [BlackBoxEvent:R-RNO-9670673] FIX is secreted - Rattus norvegicus [Reaction:R-RNO-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) - Rattus norvegicus [BlackBoxEvent:R-RNO-9661625] FVIII is secreted - Rattus norvegicus [Reaction:R-RNO-5607023] factor IXa associates with cell membrane - Rattus norvegicus [Reaction:R-RNO-5607043] factor VIIIa associates with cell membrane - Rattus norvegicus [Reaction:R-RNO-158278] factor VIIIa + factor IXa -> factor VIIIa:factor IXa - Rattus norvegicus [Reaction:R-RNO-158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9769743] Amplification and propagation of coagulation cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Amplification and propagation of coagulation cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9769743
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9769740] Coagulation pathway
(inferredTo)	[Pathway:R-HSA-9769743] Amplification and propagation of coagulation cascade

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