Reactome | factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)

Schema > Reaction > Entries

factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10114747] serine-type endopeptidase activity of factor VIIIa:factor IXa [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10114766
displayName	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)
eventOf	[Pathway:R-RNO-9769743] Amplification and propagation of coagulation cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) - Homo sapiens
input	20 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [Complex:R-RNO-140739] factor X [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) activation of factor X by VIIIa:IXa
output	[EntityWithAccessionedSequence:R-RNO-140785] F10 [extracellular region] [Complex:R-RNO-140689] factor Xa [extracellular region]
precedingEvent	[Reaction:R-RNO-158278] factor VIIIa + factor IXa -> factor VIIIa:factor IXa - Rattus norvegicus
regulatedBy	[NegativeRegulation:10114767] Negative regulation by 'FVIIIa:FIXa:PROS1 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-158164
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9769743] Amplification and propagation of coagulation cascade
(inferredTo)	[Reaction:R-HSA-158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)

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