Reactome | Drug-mediated inhibition of CDK4/CDK6 activity

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225373
displayName	Drug-mediated inhibition of CDK4/CDK6 activity
eventOf	[Pathway:R-RNO-69231] Cyclin D associated events in G1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9754130] CDK4 inhibitors bind CDK4 - Rattus norvegicus [Reaction:R-RNO-9754129] CDK6 inhibitors bind CDK6 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Drug-mediated inhibition of CDK4/CDK6 activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9754119
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-69231] Cyclin D associated events in G1
(inferredTo)	[Pathway:R-HSA-9754119] Drug-mediated inhibition of CDK4/CDK6 activity

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