Reactome | Drug-mediated inhibition of CDK4/CDK6 activity

Schema > Pathway > Entries

Drug-mediated inhibition of CDK4/CDK6 activity Show undefined attributes

authored	[InstanceEdit:9754145] Orlic-Milacic, Marija, 2021-09-21
created	[InstanceEdit:9754122] Orlic-Milacic, Marija, 2021-09-21
crossReference	[DatabaseIdentifier:12819489] BioModels Database:BIOMD0000000939 [DatabaseIdentifier:12819587] BioModels Database:BIOMD0000000723
dbId	9754119
displayName	Drug-mediated inhibition of CDK4/CDK6 activity
doi	10.3180/R-HSA-9754119.1
edited	[InstanceEdit:9758458] Orlic-Milacic, Marija, 2021-11-12
eventOf	[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9754130] CDK4 inhibitors bind CDK4 - Homo sapiens [Reaction:R-HSA-9754129] CDK6 inhibitors bind CDK6 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9756814] The history and future of targeting cyclin-dependent kinases in cancer therapy [LiteratureReference:9756816] CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought [LiteratureReference:9756807] Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition [LiteratureReference:9756817] Immunomodulation by anticancer cell cycle inhibitors
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Drug-mediated inhibition of CDK4/CDK6 activity
orthologousEvent	[Pathway:R-SPO-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Schizosaccharomyces pombe [Pathway:R-DDI-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Dictyostelium discoideum [Pathway:R-CEL-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Caenorhabditis elegans [Pathway:R-DME-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Drosophila melanogaster [Pathway:R-GGA-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Gallus gallus [Pathway:R-XTR-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Xenopus tropicalis [Pathway:R-DRE-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Danio rerio [Pathway:R-SSC-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Sus scrofa [Pathway:R-BTA-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Bos taurus [Pathway:R-CFA-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Canis familiaris [Pathway:R-RNO-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Rattus norvegicus [Pathway:R-MMU-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Mus musculus
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9757975] Kadambat Nair, Sisira, 2021-11-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9754119
summation	[Summation:9756809] Cyclin dependent kinases CDK4 and CDK6 regulate crucial step...

Referrals

(hasEvent)

[Pathway:R-HSA-69231] Cyclin D associated events in G1