Reactome | AKT-phosphorylated FOXO3 translocates to cytosol

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AKT-phosphorylated FOXO3 translocates to cytosol Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10211182
displayName	AKT-phosphorylated FOXO3 translocates to cytosol
eventOf	[Pathway:R-RNO-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-199289] phospho-Foxo3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	AKT-phosphorylated FOXO3 translocates to cytosol
output	[EntityWithAccessionedSequence:R-RNO-9614413] phospho-Foxo3 [cytosol]
precedingEvent	[Reaction:R-RNO-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9624527
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling
(inferredTo)	[BlackBoxEvent:R-HSA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol

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