Reactome | Egr2 and Sox10 bind the Prx promoter

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Egr2 and Sox10 bind the Prx promoter Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9619659] Rothfels, Karen, 2018-09-18
dbId	9619658
displayName	Egr2 and Sox10 bind the Prx promoter
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:R-RNO-9614791] Egr2 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-9619350] Prx gene [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-RNO-9614292] Sox10 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9615605] Interactions of Sox10 and Egr2 in myelin gene regulation [LiteratureReference:9618536] Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve [LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression [LiteratureReference:9618696] Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Egr2 and Sox10 bind the Prx promoter
orthologousEvent	[Reaction:R-HSA-9619657] EGR2 and SOX10 bind the PRX gene - Homo sapiens
output	[Complex:R-RNO-9619635] Prx gene:Egr2:Sox10 [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9619658
summation	[Summation:9619656] ChIP seq analysis shows that EGR2 and SOX10 bind to an intro...

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