Reactome | CBL:CRKL binds RAPGEF1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144935
displayName	CBL:CRKL binds RAPGEF1
eventOf	[Pathway:R-RNO-912631] Regulation of signaling by CBL - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-912734] CBL:CRKL binds RAPGEF1 - Homo sapiens
input	[Complex:R-RNO-912774] p(Y700,731,774)-CBL:CRK [cytosol] [EntityWithAccessionedSequence:R-RNO-913472] Rapgef1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL:CRKL binds RAPGEF1
output	[Complex:R-RNO-914209] p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol]
precedingEvent	[Reaction:R-RNO-912790] CBL binds CRK - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-912734
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-912631] Regulation of signaling by CBL
(inferredTo)	[Reaction:R-HSA-912734] CBL:CRKL binds RAPGEF1

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