Reactome | Regulation of signaling by CBL

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Regulation of signaling by CBL Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224001
displayName	Regulation of signaling by CBL
eventOf	[Pathway:R-RNO-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Rattus norvegicus [BlackBoxEvent:R-RNO-912627] CBL ubiquitinates PI3K - Rattus norvegicus [Reaction:R-RNO-912790] CBL binds CRK - Rattus norvegicus [Reaction:R-RNO-912734] CBL:CRKL binds RAPGEF1 - Rattus norvegicus [Reaction:R-RNO-912727] CBL binds VAV - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-912631] Regulation of signaling by CBL - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of signaling by CBL
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-912631
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
(inferredTo)	[Pathway:R-HSA-912631] Regulation of signaling by CBL

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