Reactome | phospho-Cbl [cytosol]

Schema > EntityWithAccessionedSequence > Entries

phospho-Cbl [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10197760] ubiquitin protein ligase activity of p-Y700,Y731,Y774-CBL [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-912774] p(Y700,731,774)-CBL:CRK [cytosol] - Rattus norvegicus [Complex:R-RNO-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] - Rattus norvegicus [Complex:R-RNO-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-912790] CBL binds CRK - Rattus norvegicus [Reaction:R-RNO-912727] CBL binds VAV - Rattus norvegicus [Reaction:R-RNO-8848829] CBL autoubiquitinates - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144846
displayName	phospho-Cbl [cytosol]
endCoordinate	906
hasModifiedResidue	[ModifiedResidue:10144842] O4'-phospho-L-tyrosine at 731 (in Homo sapiens) [ModifiedResidue:10144843] O4'-phospho-L-tyrosine at 700 (in Homo sapiens) [ModifiedResidue:10144844] O4'-phospho-L-tyrosine at 774 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-912656] p-Y700,Y731,Y774-CBL [cytosol] - Homo sapiens
maxDepth	1
name	phospho-Cbl p-Y700,Y731,Y774-CBL A0A8I6G3R2
producedByEvent	[Reaction:R-RNO-8848818] PTK6 phosphorylates CBL - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I6G3R2] UniProt:A0A8I6G3R2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-912656
startCoordinate	1

Referrals

(input)	[Reaction:R-RNO-912790] CBL binds CRK [Reaction:R-RNO-912727] CBL binds VAV [Reaction:R-RNO-8848829] CBL autoubiquitinates
(hasComponent)	[Complex:R-RNO-912774] p(Y700,731,774)-CBL:CRK [cytosol] [Complex:R-RNO-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] [Complex:R-RNO-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-RNO-912755] p(Y700,731,774)-CBL:VAV1 [cytosol]
(physicalEntity)	[CatalystActivity:10197760] ubiquitin protein ligase activity of p-Y700,Y731,Y774-CBL [cytosol]
(output)	[Reaction:R-RNO-8848818] PTK6 phosphorylates CBL
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-912656] p-Y700,Y731,Y774-CBL [cytosol]