Reactome | AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU

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AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU Show undefined attributes

catalystActivity	[CatalystActivity:10205332] metalloendopeptidase activity of C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane]
category	omitted
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10205334
displayName	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU
eventOf	[Pathway:R-RNO-8949664] Processing of SMDT1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8949659] AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-8949227] SMDT1 [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU
precedingEvent	[Reaction:R-RNO-8949649] PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8949659
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8949664] Processing of SMDT1
(inferredTo)	[BlackBoxEvent:R-HSA-8949659] AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU

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