Reactome | ATF6B (ATF6-beta) activates chaperones

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created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225061
displayName	ATF6B (ATF6-beta) activates chaperones
eventOf	[Pathway:R-RNO-381119] Unfolded Protein Response (UPR) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:161539] endoplasmic reticulum unfolded protein response
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-8874145] MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) - Rattus norvegicus [BlackBoxEvent:R-RNO-8874137] ATF6B (ATF6-beta) translocates from the cytosol to the nucleus - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-8874177] ATF6B (ATF6-beta) activates chaperones - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	ATF6B (ATF6-beta) activates chaperones
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8874177
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-381119] Unfolded Protein Response (UPR)
(inferredTo)	[Pathway:R-HSA-8874177] ATF6B (ATF6-beta) activates chaperones

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