Reactome | ATF6B (ATF6-beta) activates chaperones

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ATF6B (ATF6-beta) activates chaperones Show undefined attributes

authored	[InstanceEdit:8874175] May, Bruce, 2016-05-15
created	[InstanceEdit:8874160] May, Bruce, 2016-05-21
dbId	8874177
displayName	ATF6B (ATF6-beta) activates chaperones
doi	10.3180/R-HSA-8874177.2
edited	[InstanceEdit:8874175] May, Bruce, 2016-05-15
eventOf	[Pathway:R-HSA-381119] Unfolded Protein Response (UPR) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161539] endoplasmic reticulum unfolded protein response
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8874162] ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein - Homo sapiens [BlackBoxEvent:R-HSA-8874138] ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi - Homo sapiens [Reaction:R-HSA-8874145] MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) - Homo sapiens [Reaction:R-HSA-8874122] MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) - Homo sapiens [BlackBoxEvent:R-HSA-8874137] ATF6B (ATF6-beta) translocates from the cytosol to the nucleus - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8874816] Transcriptional regulation of secretory capacity by bZip transcription factors [LiteratureReference:8874172] Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response [LiteratureReference:8874829] Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response [LiteratureReference:381018] Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction [LiteratureReference:8874812] Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability [LiteratureReference:8874124] N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha [LiteratureReference:9965889] CRISPR-Cas9-Mediated ATF6B Gene Editing Enhances Membrane Protein Production in HEK293T Cells
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ATF6B (ATF6-beta) activates chaperones
orthologousEvent	[Pathway:R-DDI-8874177] ATF6B (ATF6-beta) activates chaperones - Dictyostelium discoideum [Pathway:R-CEL-8874177] ATF6B (ATF6-beta) activates chaperones - Caenorhabditis elegans [Pathway:R-DME-8874177] ATF6B (ATF6-beta) activates chaperones - Drosophila melanogaster [Pathway:R-SSC-8874177] ATF6B (ATF6-beta) activates chaperones - Sus scrofa [Pathway:R-BTA-8874177] ATF6B (ATF6-beta) activates chaperones - Bos taurus [Pathway:R-CFA-8874177] ATF6B (ATF6-beta) activates chaperones - Canis familiaris [Pathway:R-RNO-8874177] ATF6B (ATF6-beta) activates chaperones - Rattus norvegicus [Pathway:R-MMU-8874177] ATF6B (ATF6-beta) activates chaperones - Mus musculus
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2023-06-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966319] Kadambat Nair, Sisira, 2025-09-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8874177
summation	[Summation:8874819] Like its homolog ATF6 (reviewed in Fox and Andrew 2015), ATF...
updateTrackers	[UpdateTracker:9971797] Update Tracker - [Pathway:8874177] ATF6B (ATF6-beta) activates chaperones - v95:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9971797] Update Tracker - [Pathway:8874177] ATF6B (ATF6-beta) activates chaperones - v95:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-381119] Unfolded Protein Response (UPR)

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