Reactome | Reelin signalling pathway

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225015
displayName	Reelin signalling pathway
eventOf	[Pathway:R-RNO-422475] Axon guidance - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-8854466] VLDLR binds RELN - Rattus norvegicus [Reaction:R-RNO-8855232] RELN:VLDLR binds DAB1 - Rattus norvegicus [Reaction:R-RNO-8855259] RELN:VLDLR:DAB1 binds SH3KBP1 - Rattus norvegicus [Reaction:R-RNO-8855237] FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-8866376] Reelin signalling pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Reelin signalling pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8866376
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-422475] Axon guidance
(inferredTo)	[Pathway:R-HSA-8866376] Reelin signalling pathway