Reactome | PLK1 phosphorylates GTSE1

Schema > Reaction > Entries

PLK1 phosphorylates GTSE1 Show undefined attributes

catalystActivity	[CatalystActivity:10198770] protein serine/threonine kinase activity of GTSE1:p-T210-PLK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10198772
displayName	PLK1 phosphorylates GTSE1
eventOf	[Pathway:R-RNO-8852276] The role of GTSE1 in G2/M progression after G2 checkpoint - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8852331] GTSE1 translocates to the nucleus - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:2266781] positive regulation of protein localization to nucleus
inferredFrom	[Reaction:R-HSA-8852317] PLK1 phosphorylates GTSE1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-8852323] GTSE1:p-T210-PLK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PLK1 phosphorylates GTSE1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-8852316] phospho-Gtse1 [cytosol] [EntityWithAccessionedSequence:R-RNO-3000318] phospho-p-T210-PLK1 [cytosol]
precedingEvent	[Reaction:R-RNO-8852324] GTSE1 binds PLK1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8852317
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8852276] The role of GTSE1 in G2/M progression after G2 checkpoint
(precedingEvent)	[Reaction:R-RNO-8852331] GTSE1 translocates to the nucleus
(inferredTo)	[Reaction:R-HSA-8852317] PLK1 phosphorylates GTSE1