Reactome | The role of GTSE1 in G2/M progression after G2 checkpoint

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The role of GTSE1 in G2/M progression after G2 checkpoint Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224999
displayName	The role of GTSE1 in G2/M progression after G2 checkpoint
eventOf	[Pathway:R-RNO-69275] G2/M Transition - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5433378] regulation of cell cycle G2/M phase transition
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-8852280] GTSE1 binds microtubule lattice in interphase cells - Rattus norvegicus [Reaction:R-RNO-8852298] GTSE1 binds MAPRE1 (EB1) at microtubule plus ends - Rattus norvegicus [Reaction:R-RNO-8852306] Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends - Rattus norvegicus [Reaction:R-RNO-8852324] GTSE1 binds PLK1 - Rattus norvegicus [Reaction:R-RNO-8852317] PLK1 phosphorylates GTSE1 - Rattus norvegicus [Reaction:R-RNO-8852331] GTSE1 translocates to the nucleus - Rattus norvegicus [Reaction:R-RNO-8852337] GTSE1 binds TP53 - Rattus norvegicus [Reaction:R-RNO-8852351] GTSE1 promotes translocation of TP53 to the cytosol - Rattus norvegicus [BlackBoxEvent:R-RNO-8852354] GTSE1 facilitates proteasome-mediated degradation of TP53 - Rattus norvegicus [Reaction:R-RNO-8852362] GTSE1 binds CDKN1A - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-8852276] The role of GTSE1 in G2/M progression after G2 checkpoint - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	The role of GTSE1 in G2/M progression after G2 checkpoint
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8852276
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-69275] G2/M Transition
(inferredTo)	[Pathway:R-HSA-8852276] The role of GTSE1 in G2/M progression after G2 checkpoint

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